The Rams travel north to face the 49ers in an NFC West battle on "Monday Night Football." If Los Angeles earns the victory in the Week 10 matchup, it will be tied with the Cardinals atop the division at 8-2.
LA will be counting on quarterback Matthew Stafford, who is coming off a two-interception game in a Week 9 loss to the Titans. No. 1 wide receiver Cooper Kupp and new wideout Odell Beckham Jr. will be his main targets. Beckham will be making his Rams debut after signing with the team Thursday. No. 2 receiver Robert Woods is out for the season after he suffered a torn ACL in practice Friday. Kupp leads the NFL with 1,019 receiving yards and 10 receiving touchdowns.
Stafford, however, will be going up against the NFL's top-ranked pass defense. End Nick Bosa leads the 49ers with seven sacks and 12 tackles for loss.
MORE: Is Odell Beckham Jr. playing tonight?
49ers quarterback Jimmy Garoppolo threw for a season-high 326 yards, with two touchdowns and an interception, in the team's 31-17 loss to the Cardinals last week. He connected with tight end George Kittle on six receptions for 109 yards and a touchdown, and he found wide receiver Brandon Aiyuk six times for 89 yards and a touchdown. Deebo Samuel leads the 49ers with 882 receiving yards.
The Rams have linebacker Von Miller available to pressure Garoppolo. Miller is making his LA debut, as well; he sat out last week's game with an ankle injury after being acquired from the Broncos at the NFL trade deadline Nov. 2. Leonard Floyd is the Rams' sack leader with 7.5. All-Pro defensive tackle Aaron Donald is next with six.
LA enters the game as a 3 1/2-point road favorite, according to FanDuel.
MORE: Is Von Miller playing tonight?
Sporting News is tracking live scoring updates and highlights from 49ers vs. Rams on "Monday Night Football." Follow below for complete results from the NFL Week 10 prime-time game.
MORE: Watch 49ers vs. Rams live with fuboTV (7-day trial)
49ers vs. Rams score
| Q1 | Q2 | Q3 | Q4 | F | |
| 49ers | 14 | 0 | - | - | - |
| Rams | 0 | 7 | - | - | - |
49ers vs. Rams live updates, highlights from 'Monday Night Football'
All times Eastern.
8:59 p.m.: Garoppolo completes to Samuel on the following play for a 20-yard gain. Mitchell picks up another 13 yards to give the 49ers a first down at the Rams' 31.
8:54 p.m.: Aaron Donald makes the stop for the Rams on third down by bringing down Mitchell for a loss of two yards. After Floyd gets called for an offsides penalty, the 49ers convert for a first down at their own 22.
8:50 p.m.: TOUCHDOWN RAMS. Stafford fires a short pass up the middle to Higbee in the end zone for the score. Rams cut the 49ers' lead 14-7 with 13:20 remaining in the half.
8:45 p.m.: Stafford completes to Beckham and runs to the 49ers 11 for a 13-yard gain.
First Quarter: 49ers 14, Rams 0
8:38 p.m.: PICK-SIX, 49ERS. A pass from Stafford bounces out of Higbee's hands, and Ward is there to make the pick at the 27 and rushes into the end zone for the score. The interception marks Stafford's fourth pick in two games. 49ers lead 14-0 with 49 seconds remaining in the first quarter.
8:34 p.m.: Andrew Whitworth gets called for a personal foul penalty that pushes the Rams back to their own 16.
8:32 p.m.: TOUCHDOWN 49ERS. Garoppolo fires a short right pass to Kittle to complete the 93-yard scoring drive. 49ers take a 7-0 lead with 1:54 remaining in the first quarter.
8:26 p.m.: Garoppolo keeps it on third down and rushes two yards to give the 49ers a first down at the Rams' 39.
8:22 p.m.: Garoppolo finds Kittle at the first down marker and is pushed out of bounds at the 49ers' 40 for an 18-yard gain.
8:20 p.m.: Von Miller makes his debut on defense alongside Aaron Donald and Leonard Floyd.
8:19 p.m.: INTERCEPTION, 49ERS. Stafford attempts a deep pass to Beckham, but Jimmie Ward picks it off at the 49ers' 7.
8:17 p.m.: Stafford connects with Beckham Jr. on the opening pass for a five-yard gain.
8:15 p.m.: 49ers win the coin toss and defer. Rams start with the ball at the 25.
What channel is 49ers vs. Rams on today?
- TV channel (national): ESPN
- Manningcast: ESPN2
- Live stream: Watch ESPN, fuboTV
49ers vs. Rams will be televised nationally on ESPN. Steve Levy, Brian Griese and Louis Riddick will broadcast the "Monday Night Football" game from the booth. Lisa Salters will report from the sidelines.
The Manningcast rreturns in Week 10. Of note, the Manningcast Curse is probably as real as the Madden Curse, but Josh Allen’s Bills losing to the Jaguars in Week 9 is hard to ignore.
Viewers in Canada can watch the game on DAZN free with a 30-day trial.
49ers vs. Rams start time
- Date: Monday, Nov. 15
- Kickoff: 8:15 p.m. ET | 5:15 PT
As this is a West Coast matchup, the game will kick off at 5:15 p.m. local time, but it have the standard "Monday Night Football” 8:15 p.m. ET kickoff time.
49ers schedule 2021
| Week | Date | Opponent | Time (ET) | TV |
| 10 | Nov. 15 | vs. Rams | 8:15 p.m. | ESPN |
| 11 | Nov. 21 | at Jaguars | 1 p.m. | Fox |
| 12 | Nov. 28 | vs. Vikings | 4:25 p.m. | Fox |
| 13 | Dec. 5 | at Seahawks | 8:20 p.m. | NBC |
| 14 | Dec. 12 | at Bengals | 1 p.m. | CBS |
| 15 | Dec. 19 | vs. Falcons | 4:05 p.m. | CBS |
| 16 | Dec. 23 (Thu.) | at Titans | 8:20 p.m. ET | NFL Network |
| 17 | Jan. 2 | vs. Texans | 4:05 p.m. ET | CBS |
| 18 | Jan. 9 | at Rams | 4:25 p.m. ET | Fox |
Rams schedule 2021
| Week | Date | Opponent | Time (ET) | TV |
| 10 | Nov. 15 (Mon.) | at 49ers | 8:15 p.m. | ESPN |
| 11 | BYE | — | — | — |
| 12 | Nov. 28 | at Packers | 4:25 p.m. | Fox |
| 13 | Dec. 5 | vs. Jaguars | 4:25 p.m. | CBS |
| 14 | Dec. 13 (Mon.) | at Cardinals | 8:15 p.m. | ESPN |
| 15 | Dec. 19 | vs. Seahawks | 4:25 p.m. | Fox |
| 16 | Dec. 26 | at Vikings | 1 p.m. | Fox |
| 17 | Jan. 2 | at Ravens | 4:25 p.m. | Fox |
| 18 | Jan. 9 | vs. 49ers | 4:25 p.m. | Fox |
'Monday Night Football' schedule 2021
| Week | Date | Matchup |
| Week 1 | Sept. 13 | Las Vegas Raiders vs. Baltimore Ravens |
| Week 2 | Sept. 20 | Green Bay Packers vs. Detroit Lions |
| Week 3 | Sept. 27 | Dallas Cowboys vs. Philadelphia Eagles |
| Week 4 | Oct. 4 | Los Angeles Chargers vs. Las Vegas Raiders |
| Week 5 | Oct. 11 | Baltimore Ravens vs. Indianapolis Colts |
| Week 6 | Oct. 18 | Tennessee Titans vs. Buffalo Bills |
| Week 7 | Oct. 25 | Seattle Seahawks vs. New Orleans Saints |
| Week 8 | Nov. 1 | Kansas City Chiefs vs. New York Giants |
| Week 9 | Nov. 8 | Pittsburgh Steelers vs. Chicago Bears |
| Week 10 | Nov. 15 | San Francisco 49ers vs. Los Angeles Rams |
| Week 11 | Nov. 22 | Tampa Bay Buccaneers vs. New York Giants |
| Week 12 | Nov. 29 | Washington Football Team vs. Seattle Seahawks |
| Week 13 | Dec. 6 | Buffalo Bills vs. New England Patriots |
| Week 14 | Dec. 13 | Arizona Cardinals vs. Los Angeles Rams |
| Week 15 | Dec. 20 | Chicago Bears vs. Minnesota Vikings |
| Week 16 | Dec. 27 | New Orleans Saints vs. Miami Dolphins |
| Week 17 | Jan. 3 | Pittsburgh Steelers vs. Cleveland Browns |
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